Basic and clinical immunology – 3022. Inhibitory action of fexofenadine hydrochloride on mast cell activation in vitro
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چکیده
Background Allergic rhinitis is well known to be accompanied by inflammatory responses in the nasal wall and lumen including predominant infiltration of eosinophils, T cells and mast cells. With the discovery of IgE as the link between allergen exposure and mediator release, mast cells established their role as effector cells in the development and maintenance of allergic diseases. However, the influence of histamine H1-receptor antagonists on mast cells activation is not fully understood. The present study, therefore, was undertaken to examine the influence of histamine H1-receptor antagonist on mast cells activation by using an in vitro cell culture technique and fexofenadine hydrochloride (FEX).
منابع مشابه
Basic and clinical immunology – 3023. Influence of fexofenadine hydrochloride on uteroglobin production from nasal epithelial cells in vitro and in vivo
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